Estradiol is a form of estrogen, a female sex hormone that controls lots of processes in the body. Some estradiol products, as estrace vaginal cream, placed directly into the vaginal area are used for “local” treatment of vaginal menopause symptoms including the secretions and surrounding tissues of the vagina. Other vaginal estradiol products are used for dealing with menopause symptoms impacting the vaginal area along with other parts of the body (such as hot flashes). This type of vaginal estradiol has “systemic” effects, suggesting that it can impact parts of the body other than where the medicine is positioned or used.
What are in the article?
Estrace Vaginal Cream Usage
The info in this leaflet specifies to estrace vaginal cream items that are used for local treatment of symptoms. Estradiol vaginal (local) is used to treat vaginal symptoms of menopause such as dryness, burning, and itching.
Estradiol vaginal (local) might likewise be used for purposes not noted in this medication guide.
You need to not use estradiol if you have: liver disease, a bleeding disorder, uncommon vaginal bleeding, history of a hormone-dependent cancer (such as breast, uterine, ovarian, or thyroid cancer), or if you have actually ever had a cardiac arrest, stroke, or a blood clot.
Do not use if you are pregnant.
Estradiol might increase your risk of establishing a condition that may result in uterine cancer. Call your doctor simultaneously if you have any unusual vaginal bleeding while using this medicine.
Estradiol must not be used to prevent heart disease, stroke, or dementia, because this medication may actually increase your risk of developing these conditions. Long-term use might also increase your risk of breast cancer or blood clot.
Your doctor should check your development regularly (every 3 to 6 months) to figure out whether you must continue this treatment.
You should not use this medication if you are allergic to estradiol, if you are pregnant, or if you have:
- uncommon vaginal bleeding that a doctor has not examined;
- liver disease;
- a bleeding or blood-clotting disorder;
- a recent history of cardiac arrest or stroke;
- a history of hormone-dependent cancer (such as breast, uterine, ovarian, or thyroid cancer); or
- if you have actually ever had a blood clot (specifically in your lung or your lower body).
Estradiol must not be used to prevent heart disease, stroke, or dementia, because this medicine might really increase your risk of developing these conditions.
To make sure estradiol is safe for you, inform your doctor if you have:
- heart disease;
- risk factors for coronary artery disease (such as diabetes, lupus, smoking cigarettes, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, or if you have had a hysterectomy);
- a history of jaundice triggered by pregnancy or birth control pills;
- hereditary angioedema (a body immune system disorder);
- a thyroid disorder;
- kidney disease;
- epilepsy or other seizure disorder;
- porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nerve system);
- endometriosis or uterine fibroid tumors;
- gallbladder disease;
- high or low levels of calcium in your blood; or
- if you have had your uterus eliminated (hysterectomy).
Long-term use of estradiol may increase your risk of breast cancer, heart attack, stroke, or embolism. Talk with your doctor about your private risks prior to using estradiol vaginal long term.
FDA pregnancy classification X. Estradiol can damage an unborn baby or cause birth defects. Do not use if you are pregnant. Tell your doctor right now if you become pregnant during treatment. Use reliable birth control while you are using this medication.
Estradiol can pass into breast milk. This medication may slow breast milk production. Tell your doctor if you are breast-feeding a baby.
Estrace Vaginal Cream Side Effects
Get emergency situation medical assistance if you have any of these signs of an allergic reaction: hives; problem breathing; swelling of your face, lips, tongue, or throat.
Remove the vaginal ring and look for emergency situation medical attention if you have: fever with nausea, vomiting, diarrhea, muscle pain, dizziness, fainting, and/or sunburn-like skin rash. These may be signs of a lethal disease called toxic shock syndrome.
Call your doctor at once if you have:
- unusual vaginal bleeding;
- swelling or inflammation in your stomach;
- jaundice (yellowing of the skin or eyes);
- memory issues, confusion;
- a lump in your breast;
- dangerously high blood pressure – severe headache, blurred vision, pounding in your neck or ears, nosebleed, stress and anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats, seizure;
- cardiac arrest symptoms – chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
- high blood sugar – increased thirst, increased urination, hunger, dry mouth, fruity breath odor, sleepiness, dry skin, blurred vision, weight loss;
- high levels of calcium in your blood – nausea, vomiting, constipation, increased thirst or urination, muscle pain or weak point, joint pain, confusion, and sensation tired or agitated;
- low levels of calcium in your blood – numbness or tingly feeling around your mouth, quick or slow heart rate, muscle tightness or contraction, overactive reflexes;
- signs of a stroke – abrupt numbness or weak point (specifically on one side of the body), unexpected severe headache, slurred speech, problems with vision or balance;
- signs of a blood clot in the lung – chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or.
- signs of a blood clot in your leg – pain, swelling, heat, or redness in one or both legs.
Typical side effects may consist of:
- light vaginal bleeding or spotting;
- nausea, vomiting, stomach pain;
- vaginal itching or discharge;
- breast pain; or
- swelling, bloating, weight gain.
Estrace Vaginal Cream Weight Gain Side Effect
Vaginal estrogen creams can cause systemic symptoms. Using Estrace vaginal cream as well as using 0.05 gr at night the next day your breasts can be bigger and get fluid retention from them as well.
Using an estrace vaginal cream 3 times a week for vaginal dryness might cause headaches, bloating and weight gain around a belly.
This is not a total list of side effects and others may take place. Call your doctor for medical recommendations about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Estrace Vaginal Cream Interactions
Avoid using other vaginal products without your doctor’s recommendations.
Grapefruit and grapefruit juice might interact with estradiol and result in undesirable side effects. Discuss the use of grapefruit items with your doctor.
Other drugs may interact with estradiol, including prescription and over the counter medications, vitamins, and organic items. Tell each of your health care suppliers about all medicines you use now and any medication you begin or stop using.
Estrace Vaginal Cream Dosage
Follow all instructions on your prescription label. Do not take this medication in larger or smaller quantities or for longer than recommended.
Estradiol might increase your risk of developing a condition that might cause uterine cancer. Your doctor might recommend a progestin to take while you are using estradiol, to help reduce this risk. Report any unusual vaginal bleeding right away.
This medication includes patient instructions for safe and efficient use. Follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
Wash your hands before and after inserting estrace vaginal cream.
You ought to not be able to feel the vaginal ring once it is in place. Leave the vaginal ring in location for 90 days, then remove it. Your doctor might want you to replace it with a brand-new ring.
Use the applicator offered to determine the recommended dosage of estrace vaginal cream. Take apart the cream applicator and wash it with moderate soap and warm water after each use.
Each estradiol vaginal tablet is provided in a single-use disposable applicator. Toss the tablet applicator away after one use.
Your doctor ought to inspect your development on a regular basis (every 3 to 6 months) to identify whether you ought to continue this treatment. Self-examine your breasts for swellings on a monthly basis, and have regular mammograms while using estradiol transdermal.
If you need surgery or medical tests or if you will be on bed rest, you might need to stop using this medicine for a brief time. Any doctor or surgeon who treats you need to understand that you are using estradiol.
Store at space temperature far from moisture and heat. Keep the vaginal ring in its protective pouch till you are ready to use it.
Look for emergency medical attention or call the Poison Help line at . Overdose symptoms might include nausea, vomiting, and vaginal bleeding.
Use the missed dosage as quickly as you keep in mind. Avoid the missed out on dose if it is nearly time for your next arranged dose. Do not use extra medication to make up the missed out on dosage. Remove the vaginal ring and insert a brand-new one as soon as you keep in mind. Do not use an extra vaginal ring to make up the missed wearing time.